SIRTMAX Blood Sugar Support

SIRTMAX® is a patented black turmeric extract, scientifically validated to address the increasing prevalence of metabolic diseases such as diabetes and hyperglycemia. These conditions are increasingly common due to high-calorie diets and low physical activity levels, highlighting the urgent need for effective management strategies to improve both short-term and long-term health outcomes.

Managing Blood Sugar Levels:

In our modern world, maintaining optimal blood sugar levels is crucial. Both fasting and postprandial (after meal) blood sugar levels are important markers of metabolic health. Elevated postprandial blood sugar can indicate insulin resistance and poor glucose tolerance, which are significant risk factors for developing type 2 diabetes, cardiovascular diseases, and other serious health conditions.

The Role of Glycation:

Glycation, a process where simple sugars attach to proteins and cellular lipids, significantly impacts skin aging and overall health. This leads to the formation of advanced glycation end products (AGEs), which promote chronic inflammation, vascular aging, and are key factors in the development of diabetic complications.

Derived from Tradition, Backed by Science:

SIRTMAX® is derived from Kaempferia parviflora, also known as 'Kra chai Dam' or Thai ginseng, a plant native to Southeast Asia traditionally used to reduce blood glucose levels and improve blood flow. This potent extract is standardized to contain no less than 3.5% of 3,5,7,3',4'-pentamethoxyflavone, 4% of 5,7-dimethoxyflavone, and 15% of total polymethoxyflavonoids, known for their significant anti-aging properties.

Clinically Proven Benefits:

SIRTMAX® has been shown to be five times more potent than resveratrol in activating the SIRT1 longevity gene and fifteen times more effective than aminoguanidine in preventing glycation. These properties help manage and prevent the exacerbation of chronic metabolic diseases by controlling blood sugar levels and reducing HbA1c, a measure of long-term glucose control.

A rigorous double-blind, placebo-controlled human study demonstrated that a daily intake of 100 mg of SIRTMAX® helped reduce body weight, maintain healthy blood sugar levels, decrease the production of AGEs, and showed a trend towards improved arterial flexibility.

SIRTMAX® Clinical Evidence:

• Metabolic Health and Obesity Management:

A study published in Fitoterapia by Shimada et al., 2011, explored the effects of the ethyl acetate extract of Kaempferia parviflora on obesity and metabolic diseases. Results indicated significant suppression of body weight increase, visceral fat accumulation, and improvements in insulin resistance, hypertension, and fatty liver conditions in a mouse model.

• Cardiovascular Health and Glycemic Control:

Another study by Shimada N, et al., 2015, published in Japanese Pharmacology and Therapeutics, evaluated the efficacy of Kaempferia parviflora extract in reducing body weight and fasting blood glucose levels, with reported improvements in vascular function, particularly in subjects with mild hyperglycemia.

• Blood Pressure and Kidney Health:

In a study published in the Journal of Renal Nutrition by Khajedehi P, et al., 2011, turmeric supplementation was shown to decrease proteinuria, hematuria, and systolic blood pressure in patients with lupus nephritis, suggesting its potential as an effective adjunct therapy in managing this inflammatory kidney disease.

SIRTMAX® stands as a critical component in combating metabolic and age-related diseases, offering a scientifically validated, natural solution to those seeking effective health management options.

Black Turmeric (Kaempferia Parviflora):

Black turmeric is also known as Thai ginseng, boasts a deep-rooted history in the traditional medicine of Southeast Asia. Celebrated for its robust phytochemical profile, this plant's dark purple-black rhizomes are a rich source of flavonoids and diarylheptanoids. These compounds are key to its acclaimed antioxidant and anti-inflammatory effects, which contribute significantly to its health benefits.

In recent years, black turmeric has attracted scientific attention for its potential to enhance metabolic health and support cardiovascular function. Its ability to improve blood flow and regulate blood glucose levels makes it an invaluable component of dietary supplements aimed at health optimization.

Recent clinical studies have further explored the potential health benefits of black turmeric, shedding light on its efficacy and safety in a contemporary health context. These studies provide compelling evidence supporting the traditional uses of black turmeric, enhancing its credibility and relevance in today’s health supplement market.

Banaba Leaf (Lagerstroemia Speciosa):

Lagerstroemia speciosa, commonly known as Banaba, is a plant that has long been used in Southeast Asia as a traditional remedy for diabetes. This herbaceous plant is widely recognized for its powerful anti-diabetic properties due to its rich content of active substances that influence glucose metabolism in beneficial ways.

Historical and Cultural Significance:

Historically, Banaba has been an integral part of folk medicine across Southeast Asia, where it is not only consumed as a health supplement but also in various forms such as tea and medicinal wines. In Japan, it has been officially recognized as a functional food, highlighting its established efficacy and safety profile.

Active Components and Their Effects:

The leaves of Banaba are particularly noted for containing corosolic acid, a substance that significantly reduces blood sugar levels by facilitating the transport of sugar from the bloodstream into the cells. This process not only lowers fasting blood sugar levels but also helps in maintaining energy balance within the cells.

Additionally, Banaba leaves contain various compounds such as ellagitannins and flavonoids, which have been shown to have a range of health benefits, including anti-inflammatory and antioxidant properties. These compounds help to slow down the breakdown of starches into glucose, which assists in managing spikes in blood sugar levels after meals.

Clinical Research and Health Benefits:

Research has consistently shown that Banaba effectively reduces high fasting blood sugar levels. One study highlighted in the journal Evid Based Complement Alternat Med (2012) discusses how Banaba and its component, corosolic acid, manage diabetes and its complications through various mechanisms, including enhanced glucose uptake and reduced sugar hydrolysis.

Another significant study published in Diabetes Research and Clinical Practice (2006) demonstrated that corosolic acid significantly lowers post-meal blood sugar levels in humans, showcasing its potential for managing postprandial hyperglycemia.

Banaba works through several mechanisms:

• Enhanced Glucose Uptake: It boosts glucose absorption into cells, reducing blood sugar levels.
• Digestive Enzyme Inhibition: It slows carbohydrate breakdown, delaying glucose release into the bloodstream.
• Anti-inflammatory and Antioxidant Support: Banaba fights inflammation and neutralizes free radicals, which are linked to many chronic diseases including diabetes.

Banaba’s diverse effects on glucose and lipid metabolism make it a beneficial ingredient in dietary supplements aimed at improving metabolic health. Its natural properties support balanced blood sugar levels and offer broad health benefits, making it an excellent choice for those seeking natural ways to enhance their wellbeing.

Salacia Extract:

Salacia Extract is a traditional Ayurvedic Remedy for Diabetes Management.

Salacia, a plant traditionally used in Ayurvedic medicine, grows in Sri Lanka and India. It's known for its ability to suppress glycolytic enzymes, which helps slow down the absorption of sugar in the intestines and control blood sugar spikes after meals.

According to tradition, the royal families in the regions where Salacia grows would drink water from bowls made of this plant to combat diabetes. This practice underscores the historical and cultural importance of Salacia in managing diabetes.

Salacia works by inhibiting enzymes that break down carbohydrates in the small intestine, such as alpha-glucosidase. By blocking these enzymes, Salacia slows the conversion of carbohydrates into simple sugars, preventing rapid spikes in blood glucose levels post-meal. The active compounds in Salacia, like salacinol, have been shown to have effects similar to those of the pharmaceutical alpha-glucosidase inhibitor acarbose.

Clinical Efficacy:

Salacia has been substantiated in Japan as a functional food, recognized for its health benefits, particularly in diabetic care. Studies have shown that Salacia extract can effectively reduce post-meal blood sugar levels. For instance, one study involving Salacia oblonga extract demonstrated its capability to significantly lower postprandial glycemia and insulinemia in healthy adults. This study employed a double-masked, randomized crossover design and found that a 1,000 mg dose of Salacia oblonga extract could reduce the plasma glucose and serum insulin areas under the curve significantly after meals, suggesting its potential use in managing diabetes (Patricia M Heacock et al., 2005, DOI: 10.1016/j.jada.2004.11.001).

Due to its mechanism of action and the clinical findings, Salacia extract is suggested for further investigation as a treatment for diabetes. Its ability to manage glucose levels and possibly reduce insulin resistance makes it a promising natural alternative for diabetes management.

Mulberry Leaf Extract (Kuwacha):

Mulberry leaf extract, known as Kuwacha, sourced from the white mulberry leaves cultivated in Kyushu, Japan, effectively combines traditional wisdom and modern health benefits. This extract is especially rich in 1-deoxynojirimycin (DNJ), a unique compound that inhibits the absorption of sugars in the intestines, thereby managing blood sugar spikes post-meal. This property has been highly valued for over a thousand years, as documented in Japan's oldest tea book, "Tea Yoseiiki."

Beyond its anti-diabetic properties, Kuwacha is a nutritional powerhouse, surpassing whole milk in calcium content and serving as a significant source of iron, magnesium, and zinc. These minerals are essential for overall health and particularly beneficial for those with dietary deficiencies.

Kuwacha is traditionally consumed as a tea in Japan, where it is appreciated both as a health supplement and a refreshing beverage. This caffeine-free tea is suitable for all ages and serves as a versatile culinary ingredient, much like matcha. The sustainable cultivation methods ensure that the leaves are grown organically and harvested at their nutritional peak, preserving their potent medicinal properties and rich flavor profile.

The effectiveness of Kuwacha in managing postprandial blood glucose is supported by scientific research. A study led by Toshiyuki Kimura and published in the Journal of Agricultural and Food Chemistry (DOI: 10.1021/jf062680g) demonstrates that food-grade mulberry powder enriched with DNJ can significantly suppress the elevation of blood glucose after meals. The clinical trial involved healthy volunteers who were administered varying doses of DNJ-enriched powder followed by sucrose.

Bitter Melon Extract (Momordica Charantia):

Bitter melon or Japanese bitter gourd, including the variety found in Okinawa, is utilized globally for its potent antidiabetic properties. It is not only consumed as a nutritious vegetable but also employed in traditional Chinese medicine for treating various ailments.

Research highlights that bitter melon extract enhances the production of intracellular ATP in pancreatic cells, leading to increased insulin secretion and reduced blood sugar levels post-meal. Specifically, a study published by Takumi Shimada and colleagues in the British Journal of Nutrition (DOI: 10.1017/S0007114521001082) demonstrates that the hydrophobic components of the extract significantly boost ATP production and insulin secretion, thus lowering blood glucose levels.

Additionally, another study by Ya Gao and others in Food Reviews International (DOI: 10.1080/87559129.2021.1923733) emphasizes that bitter melon improves insulin sensitivity, repairs damaged pancreatic islet β-cells, and stimulates insulin secretion. The extract also helps regulate blood sugar levels by interacting with the intestinal flora, inhibiting glucosidase and amylase, and activating AMP-activated protein kinase (AMPK) and increasing expression of peroxisome proliferator-activated receptors (PPARs).

Thus, with its multiple mechanisms of action, bitter melon extract offers a promising option for diabetes management, supporting improved glucose control and overall health. This information is valuable for both medical professionals seeking to understand the therapeutic potentials of bitter melon and individuals looking for natural ways to manage diabetes.